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KMID : 0603519990040030127
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Journal of Korean Association of Cancer Prevention
1999 Volume.4 No. 3 p.127 ~ p.135
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The Inhibition of DMBA-Induced Carcinogenesis by CHL in Hanster Buccal Pouch
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Lee Jong-Min
Chung Won-Yoon
Park Kwang-Kyun
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Abstract
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Chlorophyllin (CHL), a water-soluble derivative of chlorophyll, has been used for the treatment of several abnormal human conditions without apparent toxicity. Recent studies have revealed that CHL is antimutagenic and anticarcinogenic against various carcinogens in vitro and in vivo. In the present study, CHL exhibited dose-related inhibition of His + reversion in Salmonella typhimurium TA98 induced by 7,12-dimethylbenz[a]anthracene (DMBA). Formation of DNA adducts from DMBA was also attenuated in the presence of CHL. Topical application of CHL prior to the topical application of DMBA resulted in significant reduction in both in both incidence and multiplicity of tumors in hamster buccal pouch. These results suggest that CHL may act as a potential chemopreventive agent against oral cancer.
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KEYWORD
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Chlorophyllin, DNA adduct, Antimutagenic activity, Anticarcinogenic activity
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